Just read this in the Wikipiedia article on Coca-Cola:
Coca-Cola Corporation is the world's largest customer of natural vanilla extract. When new Coke was introduced, in 1985, the economy of Madagascar crashed, and only recovered after New Coke flopped. The reason is because New Coke uses vanillin, a less-expensive synthetic substitute, and purchases of vanilla more than halved during this period.
Interesting factoid. Whodathunkit?